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Vibramicina 100mg 10 Caps, Doxyxycline

THIS IS A BRAND MEDICATION

INDICATIONS: Doxycycline is indicated for infections caused by the following microorganisms: Rickettsiae: spotted fever Rocky Mountains, typhoid and typhus fevers, Q fever Rickettsialpox and tick fever.

Mycoplasma pneumoniae (Eaton agent, PPLO). Chlamydia psittaci, formerly agent of psittacosis and ornithosis. Chlamydia trachomatis, formerly agent of lymphogranuloma venereum.

Doxycycline is indicated in the treatment of uncomplicated infections of the urethra, the rectum or the endocervix of adults due to Chlamydia trachomatis.

Calymmatobacterium (Donovania), granulomatosis (before inguinal granuloma agents). Borrelia recurrentis and B. Dutton, spirochetes responsible for relapsing fever transmitted by lice and ticks. Ureaplasma urealyticum (mycoplasma T), as agent and nongonococcal urethritis in men associated with infertility. Plasmodium falciparum (falciparum malaria resistant to chloroquine).

The following gram-negative microorganisms:

Haemophilus ducreyi (chancroid).

Yersinia pestis (formerly Pasteurella pestis).

Francisella tularensis (formerly Pasteurella tularensis).

Bartonella bacilliformis.

Bacteroides sp.

Fusobacterium species.

Campylobacter fetus (Vibrio fetus before).

Brucella sp.

Because many strains of the following microorganisms have been shown to be resistant to tetracyclines, are recommended crops and sensitivity tests. Doxycycline is indicated in the treatment of the following infections caused by gram-negative bacteria when bacteriological tests indicate that are sensitive to it.

Neisseria gonorrhoeae.

Vibrio cholerae (formerly Vibrio comma).

Escherichia coli.

Enterobacter aerogenes.

Shigella sp.

Acinetobacter sp. (Formerly Mima sp., And Herella sp.).

Haemophilus influenzae (respiratory).

Klebsiella sp. (Respiratory and urinary tract infections).

Branhamella catarrhalis.

Doxycycline is indicated in the treatment of infections caused by Gram positive bacteria following when bacteriological tests indicate that are susceptible thereto: Streptococcus pneumoniae (Diplococcus pneumoniae before. Streptococcus sp.: Found that a certain percentage of strains of Streptococcus faecalis and Streptococcus pyogenes are resistant to tetracycline, therefore be used in Streptococcal infections once the microorganism has demonstrated sensitivity.

In the case of upper respiratory tract infections caused by hemolytic streptococci A, including prophylaxis of rheumatic fever is the antibiotic penicillin usual choice.

Staphylococcus aureus:

Respiratory infections, skin and soft tissue: Tetracyclines are not drugs of choice for the treatment of any staphylococcal infection.

When penicillin contraindicated, doxycycline is an antibiotic alternative in the management of infections:

Pertenue Treponema pallidum and Treponema (syphilis and yaws).

Listeria monocytogenes.

Clostridium sp.

Bacillus anthracis.

Leptotrichia buccalis (formerly Fusobacterium fusiforme), Vincent's infection.

Actinomyces sp.

Doxycycline can be useful in case of acute intestinal amebiasis, along with managing amebicides; also be useful therapeutic adjunct in the treatment of severe acne.

Doxycycline is indicated in the treatment of trachoma, while the causative agent, according to immunofluorescence tests, is not always eliminated.

Is indicated for the treatment of stage I of Lyme disease. Furthermore, it can treat inclusion conjunctivitis, either with single oral administration of doxycycline combining topical agents.

Doxycycline is indicated for prophylaxis in the following cases:

Typhus (Rickettsia tsutsugamushi).

Tourist diarrhea (enterotoxigenic Escherichia coli).

Malaria (in regions where Plasmodium falciparum is resistant to chloroquine).

Human Pharmacokinetics: Doxycycline is a bacteriostatic for gram-positive and gram-negative and is believed to its antibacterial effect is that inhibits protein synthesis.

Tetracyclines are easily absorbed and fixed to plasma proteins to varying degrees. Are concentrated by the liver into bile and excreted in the urine and feces in high concentrations and in a biologically active form. Doxycycline is almost completely absorbed after oral administration.

Studies reported to date indicate that the absorption of doxycycline is not changed significantly by the ingestion of foods, including milk, unlike what is observed with some tetracyclines.

After administration in normal adult volunteers at a dose of 200 mg, blood levels reached a peak of 2.6 mcg / mL after 24 hours.The studies have shown no significant difference in the half life of doxycycline (Limits of 18-22 hours) in patients with severely impaired renal function. Haemodialysis does not modify plasma half life of doxycycline.

Contraindications: Patients who have shown hypersensitivity to any of the tetracyclines.

PRECAUTIONS: As seen with other tetracyclines, doxycycline forms a stable calcium complex in any osteogenic tissue. We have seen a decrease in fibula growth rate in infants receiving 25 mg / kg oral tetracycline every 6 hours. This reaction was shown to be reversible when the drug discontinued.

The use of antibiotics may occasionally lead to the development of non-susceptible organisms. It is essential constant patient observation. If infection by resistant organisms, the antibiotic should be discontinued and appropriate therapeutic measures instituted.

When during the treatment of venereal diseases suspected syphilis coexistence should be diagnostic procedures including darkfield examination. In all these cases, monthly serological tests should be performed at least for four months.

In the long-term treatment should be performed periodic laboratory evaluations of organ systems, including hematopoietic studies, kidney and liver.

Photosensitivity was observed in some individuals taking tetracyclines, as an exaggerated sunburn. Patients who for any reason are not exposed to direct sunlight or ultraviolet radiation should be informed of this reaction by the use of tetracycline, and the first sign of redness administration should be discontinued.

Antianabolic action of tetracyclines may lead to increased BUN. Studies done to date indicate that this does not happen when using doxycycline in patients with renal insufficiency.

RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING

Use in pregnancy: Not rated doxycycline in pregnant women, so it is not recommended for use during pregnancy.

Lactation: The tetracyclines pass into the breast milk of nursing women, why they should be avoided in administration.

Use in children: The use of drugs of the tetracycline class during tooth development (last half of pregnancy, lactation and children up to 8 years of age) can lead to a permanent discoloration of the teeth (yellow-gray-brown ). This reaction is most frequent undesirable prolonged use has been observed even after repeated short treatments. Have also been reported cases of enamel hypoplasia. Therefore not be used doxycycline age groups mentioned above, unless other antibiotics are not available, which if present is unlikely to be effective or well, are contraindicated.

ADVERSE REACTIONS: Because doxycycline absorption is virtually complete, gastrointestinal adverse effects are rare. Have been observed following side effects in patients receiving tetracyclines have.

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory processes of the anogenital region (with monilial growth).

Rarely hepatic dysfunction have been reported. These reactions have been observed with the administration of tetracyclines both orally and parenterally.

Have been reported rarely esophagitis and esophageal ulcers in patients receiving oral tetracycline. Most of these patients took the medication immediately before bedtime.

Skin: maculopapular and erythematous rash. Although rare, there have been reports of exfoliative dermatitis. The photosensitivity is discussed in section precautions.

Hypersensitivity reactions: urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

It is reported bulging fontanelles in infants and benign intracranial hypertension in adults who have received therapeutic doses. These effects disappear quickly by discontinuing the administration.

When administering any tetracycline for prolonged periods, it has been reported microscopic staining dark brown in the thyroid gland, but there are no reported functional disorders of the thyroid.

DRUG INTERACTIONS AND OTHER GENDER: Because tetracyclines have been shown to decrease plasma prothrombin activity, patients who are on anticoagulant therapy may require adjustment, lowering the dose of the anticoagulant.

Since bacteriostatic drugs may interfere with the bactericidal effect of penicillin should not be administered concomitantly doxycycline and penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium, as well as preparations containing iron and bismuth salts.

Barbiturates, alcohol, carbamazepine and phenytoin decrease the half-life of doxycycline.

CHANGES IN RESULTS OF LABORATORY TESTS

Renal toxicity: It is reported increased blood urea nitrogen when used tetracyclines apparently dose related.

Blood: There have been reports of hemolytic anemia, thrombocytopenia, and eosinophilia etropenia.

PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: Results from animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can lead to toxic effects in it ( generally related to delay in skeletal development). There has also been evidence of embryotoxicity in animals treated early in pregnancy.

DOSAGE AND ADMINISTRATION: Treatment should be continued for at least 24 or 48 hours after the symptoms and fever have subsided. In case of streptococcal infections, treatment should be continued for 10 days, to prevent the development of rheumatic fever or glomerulonephritis.

The usual dose of doxycycline in adults is 200 mg on the first day of treatment (administered in one single dose or 2 doses of 100 mg every 12 hours), followed by a maintenance dose of 100 mg / day.

In the treatment of more severe infections (particularly chronic urinary tract infections) may be administered 200 mg daily during the treatment.

Children over 8 years: The recommended dosage schedule for children weighing 50 kg or less is 4 mg / kg on the first day of treatment (in 1 or 2 shots). In more severe infections can be used up to 4 mg / kg daily. In children over 50 kg the recommended dose should be used for adults (see use in children).

Acne vulgaris: 50-100 mg daily up to 12 weeks.

Uncomplicated gonococcal infections (except anorectal infections in men): 100 mg orally, 2 times a day for 7 days. As an alternative scheme, single dose 300 mg can be given away, and an hour later, another 300 mg. The medication should be given with food, including milk or carbonated drinks.

Urethral infection, uncomplicated endocervical or adult rectal produced by Chlamydia trachomatis 100 mg orally two times a day for at least 10 days. In case of Ureaplasma urealyticum infections (mycoplasma T) in the male genital tract, the patient and her partner should be treated with 100 mg 2 times a day for 4 weeks.

Nongonococcal urethritis caused by Ureaplasma urealyticum: 100 mg orally, 2 times a day for seven days.

Primary and secondary syphilis: 300 mg daily, in divided doses for a minimum of 10 days.

Pelvic inflammatory disease in outpatients: It is recommended to apply 2 g cefoxitin intramuscularly or 3 g of amoxicillin or ampicillin 3.5 g orally or 4.8 million units of penicillin G procaine IM applied in two different places, or 250 mg of ceftriaxone IM Each of these drawings, except ceftriaxone must be accompanied by oral administration of 1 g of prebenecid, followed by 100 mg oral doxycycline, 2 times a day for 10-14 days.

Falciparum malaria resistant to chloroquine: 200 mg daily for at least 7 days. Please take a quick action schizontocide as quinine, along with doxycycline. The recommended dose of quinine varies. Prophylaxis can be started 1-2 days before travel to malarious areas. Treatment should continue for the trip and 4 weeks after leaving such areas.

Prophylaxis of malaria:

Adults: 100 mg daily.

Children over 8 years: 2 mg / kg per day with a maximum equal to the adult dose.

The louse-borne relapsing fever and tick and epidemic typhus have been successfully treated with a single oral dose of 100 or 200 mg, depending on its severity.

Selective prophylaxis and treatment of cholera in adults: 300 mg in a single dose.

Prevention of typhus: 200 mg as a single dose.

Diarrhea Prevention Economy (Adults): 200 mg during the first day of travel (administered as a single dose or 100 mg every 12 hours), followed by 100 mg daily while in the risk area. No data exists regarding prophylactic effect when using the antibiotic for more than 21 days.

Prevent leptospirosis: 100 mg orally two times a day for 7 days.

Studies done to date have indicated that administration of doxycycline in usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal failure.

Administration: It is recommended that patients ingest sufficient quantities of liquid when under treatment with oral tetracycline drugs in order to reduce the possibility of irritation or ulceration of the esophagus. If gastric irritation occurs, it is recommended that doxycycline be ingested with food or milk. Studies indicate that absorption of doxycycline is not affected significantly when ingested simultaneously with food.

MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION: The usual dose and frequency of administration of doxycycline differ from other tetracyclines. Excess in the recommended amounts may result in an increase in the frequency of side effects. No data from the prophylactic effect when using the antibiotic for more than 21 days.

In case of overdosage, discontinue medication, treat symptoms and institute supportive measures. Dialysis does not alter the serum half-life and therefore it would not be beneficial in the treatment of overdosage.

PRESENTATIONS:

Cardboard box with 10, 15 or 30 capsules of 50 mg each.

Cardboard box with 10, 15 or 30 capsules of 100 mg each.

Cardboard box with 10, 15 or 30 capsules of 200 mg each.

RECOMMENDED STORAGE: Store at room temperature not more than 30 ° C, and dry.

Protect from light.

LEGENDS OF PROTECTION

Keep out of reach of children. Its sale requires a prescription. Do not administer to children under 8 years. Do not administer to pregnant women or lactation periods. Exclusively for medical literature.
Drug Name: Vibramycin
Comparable drug patent: Vibramycin
Active ingredient: Doxycycline
Presentation: Capsules.
Concentration: 50mg
Extended-release tablets: No
Laboratory: Pfizer
Box of 28 capsules
Made In: Mexico